V.1(1) 7. Original Research: NOVEL APPROACH TO PREPARE AND EVALUATE FRUIT PEEL EXTRACT BASED SILVER NANOPARTICLES

 Vinay CH1*, Prakash Goudanavar1, Inayathulla2, Ankit Acharya1

1Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara571448, Karnataka, India.

2Department of Pharmaceutics, Farooqia College of Pharmacy, RGUHS, Mysore-570021, Karnataka, India.

ABSTRACT

Background: Silver nanoparticles have unique properties including potential therapeutic applications. Their size ranges from 1 to 100 nm and they may be extracted from different  from  various fruit-peel extracts using different novel techniques.

Objective: The main objective of the present work was to prepare pomegranate and orange peel extract based nano particles by chemical complexation method.

Methodology: Ethanolic extracts of pomegranate and orange peel were prepared by using Soxhlet apparatus and evaluated for phyto-chemical constituents.

Results: Qualitative analysis of pomegranate peel showed positive results for Alkaloids, Anthraquinones, Saponins and Terpenoids, where as orange peel showed positive results for Alkaloids, Tannin and Saponins. The percentage moisture content obtained from the two fruits (pomegranate and orange) was 72% and 96.12% respectively. The pH was found to be 3.6 and 3.8 for pomegranate and orange respectively. A zeta potential of prepared nanoparticles for pomegranate extract was found in the range of -24.6 mV to -34.5 mV (P20 & P50) and -21.4 mV to 32.0 mV (O20 & O50) for orange extract, respectively. The particle size for pomegranate extract was found in the range of 118.6 nm to 231.7 nm (P20 & P30) and 178.8 nm to 191.6 nm (O20 & O50) for orange extract, respectively.

Conclusions: Overall, the values of nanoparticles having higher surface charge indicated the least chance of aggregation and the particle size range confirmed that obtained particles were in nano range (<500 nm size). SEM results indicated the formation of nanoparticles and were relatively spherical in shape. Energy dispersive spectrometry (EDS) analysis confirmed the presence of AgNPs. The study will be further extended for anti-microbial and wound healing therapeutic properties.

Keywords: Orange peel extract, Qualitative analysis, Nano particles, Zeta potential, Particle Size.
*Corresponding Author:  vinaykalyani9743@gmail.com

This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

 

CITE:
Vinay CH, Goudanavar P, Inayathulla, Acharya A. Novel Approach to Prepare and Evaluate Fruit Peel Extract Based on Silver Nanoparticles, The International Journal of Therapeutics  2018; 1(1):44-53.

 

© 2018 Publishing services provided by The International Journal of Therapeutics (IJTHERA) Website: https://www.ijthera.com

CITE:
Vinay CH, Goudanavar P, Inayathulla, Acharya A. Novel Approach to Prepare and Evaluate Fruit Peel Extract Based on Silver Nanoparticles, The International Journal of Therapeutics  2018; 1(1):44-53.

© 2018 Publishing services provided by The International Journal of Therapeutics (IJTHERA) Website: https://www.ijthera.com 


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